Adam Silver, assistant professor of biology, recently published an article in Heliyon entitled, “Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells.” Among the co-authors of the article is Sara Buckley (Biology, ’16), a former University of Hartford undergraduate.
The circadian clock regulates nearly all aspects of physiology and behavior. The aim of this study was to determine if Toll-like receptor (immune receptors that recognize unique aspects of microorganisms) expression and responsiveness exhibit time-of-day dependent differences. The results of Silver’s study could have implications for TLR-directed chrono-immunotherapeutics.
The study can be found here: Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells