The Department of Psychology invites you to join us on Friday, October 5, 2018, Avram Holmes, Ph.D. Assistant Professor of Psychology Yale University presents “From molecules to madness: identifying network-level signatures of psychiatric illness risk”
Research in his laboratory focuses on discovering the fundamental organization of large-scale human brain networks. A core motivation that drives this work is the search for specific network-level signatures or “fingerprints” that co-vary with heritable behavioral variation in the general population and mark vulnerability for psychiatric illness onset. To date, research on the biological origins of psychopathology has largely focused on discrete illness categories. Although patient groups within this diagnostic system are treated as distinct entities, there are often murky boundaries between health and disease and across the disorders themselves. To establish the etiology of these complex syndromes, we must account for diagnostic heterogeneity, both relatively selective and disorder-spanning symptoms, and the dimensional nature of genetic risk.
In this talk, he will present two complementary lines of research. First, he will discuss our recent efforts to link spatial patterns of gene expression to the topographic organization of large-scale functional networks. Second, I will present ongoing research that uses measures of gene expression to examine the relative influence of inhibitory interneuron subtypes on brain function, cortical specialization, and human behavior. In doing so, he will highlight how this information can be leveraged to understand individual variability in the diverse processing capabilities of the human brain and associated vulnerability for psychiatric illness onset.
Please join us in East Hall 220 on October 5, 2018 from 12:30 to 1:30. Light refreshments will be served.